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Prior genetic and postmortem studies have revealed abnormalities in these neurotransmission systems in ASD: genetic studies have revealed altered single-nucleotide polymorphisms (SNPs) in genes related to Glu transporters [6], and postmortem studies have demonstrated the overexpression of mRNA encoding Glu receptors [7]

Smaragdi A, Chavez S, Lobaugh NJ, Meyer JH, Kolla NJ

In several cases, after FDA advisors recommended the agency enact safety measures over McNeils objections, the company adopted them before the agency forced it to do so

Reinforcing this dynamic, allopurinol (a xanthine oxidase inhibitor that both increases adenosine and lowers UA formation) has repeatedly demonstrated efficacy as an anti-manic adjunct in BD and in treating impulsivity/aggression in elderly patients with dementia [112, 113]